Dr. Steve Walkley is a Professor at Albert Einstein College of Medicine. His research interests are concerned with analysis of pathogenic cascades and development of therapeutic strategies for genetic disorders of the endosomal-lysosomal system known as neuronal storage diseases. Disorders include Tay-Sachs, Hurler, Sanfillippo, Niemann-Pick, Batten, and other related conditions. Primary proteins implicated in storage diseases include not only lysosomal hydrolases but also soluble and membrane associated proteins often of unknown function. His studies are focused on the link between the primary protein defect and the abnormal accumulation of substrate (gangliosides, glycosaminoglycans, cholesterol, and so forth) and with subsequent induced changes in trafficking and signaling events within affected neurons.